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AQX-1125 also exhibits >80% oral bioavailability
Smiles: CN1N=C(C=C1C1=CC=C(OCC2C=CC(Cl)=CC=2)C(=C1O)C1C=C(C=C(C=1)C(F)(F)F)C(F)(F)F)C(F)(F)F
1-Hydroxy-2-naphthoic acid is a xenobiotic metabolite produced by the biodegradation of phenanthrene by microorganisms
Increased production of vasoconstrictive prostanoids
Smiles: COC1C=C(C[C@@H]2COC(=O)[C@@]2(O)CC2C=C(OC)C(O)=CC=2)C=CC=1O
MAGL-IN-1 444296 AQX-1125 also exhibits >80% oralMAGL IN 1 is a potent, selective, reversible and competitive inhibitor of MAGL, with an IC50 of 80 nM. MAGL IN 1 exhibits anti proliferative effects against human breast, colorectal, and ovarian cancer cells. MAGL IN 1 blocks MAGL in cell based as well as in vivo assays. Product information CAS Number: 2324160 91 8 Molecular Weight: 369. 43 Formula: C22H24FNO3 Chemical Name: 4 fluoro 3 {4 [4 (propan 2 yl)benzoyl]piperidine 1 carbonyl}phenol Smiles: