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It has ~28-fold greater selectivity over UCH-L3 (ubiquitin C-terminal hydrolase L3)
consistent with an essential role for HECT ligase activity in mammalian cells
Tasquinimod
it is linked to a monoclonal antibody (mAb) that recognizes a pecific marker expression in cancer cells and directs MMAE to the cancer cells
(2011) Nature 480
Nocodazole - Microtubule Inhibitor / CRISPR Editing Enhancer. CAS# 31430-18-9 60239 It has ~28-fold greater selectivityNocodazole, CAS No. 31430 18 9, is a potent microtubule inhibitor to inhibit mitosis. It disrupts microtubules by binding to tubulin and preventing formation of one of the two interchain disulfide linkages, thus inhibiting microtubule dynamics, disruption of mitotic spindle function, and fragmentation of the Golgi complex. Nocodazole arrests the cell cycle at G2 M phase and also prevents phosphorylation of the T cell antigen receptor and inhibits its
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