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Formula: C6H6O6
Nurmemmedov E
1-3H3/b11-6+
a Chinese scientist
is a cyclooxygenase-2 inhibitor used to treat osteoarthritis
MK-0354 497 Formula: C6H6O6MK 0354 is a partial agonist of GPR109a receptor, for hGPR109a mGPR109a with EC50 of 1. 65 1. 08 M, showed no activation of GPR109b. IC50 value: 1. 65 M (EC50, for hGPR109a), 1. 08 M (EC50, for mGPR109a) Target: GPR109ain vitro: MK 0354 demonstrated clear and statistically significant partial agonism in the cAMP assays for both the mouse and human receptors with efficacy approximately 60 70% of that of either nicotinic acid or hydroxy butyrate, a