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NSC 613327
26(9):539-47
57(4):421-8
Desmethyl Erlotinib (OSI-420 free base) is an active metabolite of Erlotinib
in the cytosol
BEZ235 Tosylate 2357 (Givinostat) NSC 613327Dactolisib tosylate is also known as NVP BEZ 235 Tosylate. NVP BEZ235 is an imidazo[4,5 c]quinoline derivative that inhibits PI3K and mTOR kinase activity by binding to the ATP binding cleft of these enzymes. The IC50s for PI3K, , , are 4, 75, 7, 5 nM, respectively. It is also found to be as active against the mutant PI3KE545K or PI3KH1047R with IC50s of 5. 7 and 4. 6 nM, respectively. In human tumor cell lines, it is able to effectively and
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