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BRPF2 (100-fold) and BRPF3 (>1000-fold)
(2011) Biochem Pharmacol
and induces caspase-dependent apoptosis in leukemic cells but not in normal immature CD34+ cells
S3I-201 (NSC-74859) preferentially inhibits Stat3 DNA-binding activity over that of Stat1 (IC50 values
PD153035 HCl (ZM 252868
SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid BRPF2 (100-fold) and BRPF3 (>1000-fold)SAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low
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