IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 0232 promoted cytokine independence and blocks

promoted cytokine independence and blocks differentiation in hematopoietic cells

18(15):4104-13

13-14H2/b17-11+

Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP

but not mTORC2

IDH-C227 - IDH1 Inhibitor. CAS# 1355324-14-9 0232 promoted cytokine independence and blocksIDH C227, CAS No. 1355324 14 9, is a potent and selective IDH1 R132H inhibitor first reported in patent WO2012009678. It can inhibit the enzymatic activity of IDH1 R132H in vitro with an IC50 < 0. 1 M, and 2 HG production in HT1080 and U87MG cells with IC50 < 0. 25 M. Because the mutated form of IDH1 produces the metabolite, 2 hydroxyglutarate (2HG), which may contribute to the formation and malignant progression of gliomas as well as other forms of