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PubMed PMID: 16515549
Clin Pharmacokinet
AZ5104 display minimal off-target activity against other non-HER family kinases
2015 Jun 15
InChiKey: NDFKBGWLUHKMFY-UHFFFAOYSA-N
UF010 - HDAC Inhibitor. CAS# 537672-41-6 Catalog No.:M60278-2S PubMed PMID: 16515549UF 010, CAS No. 537672 41 6, is a Class I HDAC inhibitor (IC50 values are 0. 06, 0. 1, 0. 5 and 1. 5 M for HDACs 3, 2, 1 and 8, respectively). UF010 inhibits cancer cell proliferation via class I HDAC inhibition. This causes global changes in protein acetylation and gene expression, resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways. The isotype selectivity coupled with interesting biological
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