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Chemical Name: N-{17
or 2 g of Poloxamer 407 in 10 mL DMSO to make a 20% (w/v) stock solution
Kucerova L
2-oxazol-4-yl)(hydroxy)methyl]-1-benzofuran-5-yl}-N-[(S)-(2
Formula: C16H8Br2F6N6O
PCS1055 dihydrochloride Catalog No.:M32998-C Chemical Name: N-{17PCS1055 dihydrochloride is a potent, selective and competitive muscarinic M4 receptor antagonist with an IC50 of 18. 1 nM and a Kd of 5. 72 nM. PCS1055 dihydrochloride inhibits radioligand [3H] NMS binding to the M4 receptor with a Ki of 6. 5 nM. PCS1055 dihydrochloride exhibits >100 fold selectivity over M1 , M3 , and M5 receptors and 30 fold selectivity at the M2 receptor. PCS1055 dihydrochloride is also a potent AChE inhibitor with IC50 s of 22 nM
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