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Chemical Name: (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide tosylic acid
Formula: C22H22F3N3O3S2
82(4):341-9
Small molecule inhibition of the KRAS-PDEδ interaction impairs oncogenic KRAS signalling
It targets the enzyme active site and is primarily competitive with the substrate and noncompetitive toward the cofactor
LDN-193189 - BMP inhibitor. CAS# 1062368-24-4 423 Chemical Name: (E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide tosylic acidLDN 193189, CAS No. 1062368 24 4, is a cell permeable, highly potent and selective BMP pathway inhibitor by inhibiting BMP type I receptors ALK2 (IC50=5 nM) and ALK3 (IC50=30 nM), but not ALK4, ALK5, and ALK7 (> 0. 5 M). It prevents Smad1, Smad5, and Smad8 phosphorylation. It is a useful tool compound to modulate stem cell differentiation (for example, neural differentiation of human ESC iPSC in combination with SB431542). It was also used in animal
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