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It blocks hyperpolarization-activated inward current (If) through cyclic nucleotide-gated cation (HCN) channels in sinoatrial node cells
InChiKey: QKDDJDBFONZGBW-UHFFFAOYSA-N
5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM
Human Endogenous Metabolite
CAS Number: 2098836-54-3
MG-277 164015 It blocks hyperpolarization-activated inward currentMG 277, a molecular glue degrader, effectively induces degradation of a translation termination factor, GSPT1, with a DC50 of 1. 3 nM. MG 277 potently inhibits tumor cell growth in a p53 independent manner, with IC50s of 3. 5 nM for RS4; 11 cells and 3. 4 nM for p53 mutant RS4; 11 IRMI 2 cells, respectively. Anticancer activity. Product information CAS Number: 2411085 89 5 Molecular Weight: 774. 71 Formula: C41H42Cl2FN5O5 Chemical Name: (3'R,4'S,5'R)
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